Associations of the triglyceride-glucose index and atherogenic index of plasma with the severity of new-onset coronary artery disease in different glucose metabolic states

Autor: Xiaosheng Wu, Weiping Qiu, Huancheng Yang, Yan-Jun Chen, Jianling Liu, Guojun Zhao
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 1475-2840
DOI: 10.1186/s12933-024-02163-9
Popis: Abstract Background The triglyceride-glucose (TyG) index is considered a dependable biomarker for gauging insulin resistance. The atherogenic index of plasma (AIP) represents a marker reflecting atherosclerosis. However, there is currently no study specifically exploring the associations of these two biomarkers with the severity of new-onset coronary artery disease (CAD) under different glucose metabolic states. Therefore, this study aims to evaluate the correlations of these two biomarkers with CAD severity in patients newly diagnosed with CAD under various glucose metabolism conditions. Method Totally 570 subjects first administered coronary angiography were enrolled, including 431 first diagnosed CAD patients and 139 non-CAD patients. CAD severity was gauged by the quantity of narrowed arteries (single-vessel and multi-vessel CAD). According to WHO diabetes guidelines, glucose metabolic states were divided into normal glucose regulation (NGR), pre-diabetes mellitus (Pre-DM), and diabetes mellitus (DM). The relationships of the TyG index and AIP with CAD severity were validated by logistic regression analysis, including adjustment for traditional cardiovascular risk elements and medical treatments. Their predictive efficacy for CAD was evaluated by receiver operating characteristic (ROC) curves. Result The TyG index and AIP were independently correlated with CAD in accordance with logistic regression analysis (both P
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