Effect of chronic AICAR treatment on muscle fiber composition and enzyme activity in skeletal muscle of rats
| Autor: | Yanru Hou, Lin Su, Yajuan Zhao, Chang Liu, Duo Yao, Min Zhang, Lihua Zhao, Ye Jin |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Applied Animal Research, Vol 49, Iss 1, Pp 89-96 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0971-2119 0974-1844 09712119 |
| DOI: | 10.1080/09712119.2021.1889563 |
| Popis: | Muscle fiber is the basic unit of skeletal muscle. Muscle fiber types play a crucial role in improving meat quality. In the current study, Wistar rats were chronic injected with 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) for four weeks in order to define the 5′-AMP-activated protein kinase (AMPK) protein activity on muscle fiber composition, enzyme activity and the mRNA expression of muscle fiber type-related genes in gastrocnemius (GS) muscle. Food intake and body weight did not show a significant difference after AICAR treatment (P > .05). The AICAR treatment caused a significantly increased number and area proportion of type I muscle fiber and expression level MyHC I mRNA (P |
| Databáze: | Directory of Open Access Journals |
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