An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study

Autor: Ramcés Falfán-Valencia, Arun Narayanankutty, Juan M. Reséndiz-Hernández, Gloria Pérez-Rubio, Alejandra Ramírez-Venegas, Karol J. Nava-Quiroz, Nora E. Bautista-Félix, Gilberto Vargas-Alarcón, Manuel D. J. Castillejos-López, Andrés Hernández
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Immunology Research, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2314-8861
2314-7156
DOI: 10.1155/2018/3174868
Popis: Background. The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1/09 pandemic. Methods. We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1/09 influenza in a case-control study including 138 influenza patients (INF-P) and 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. HLA class I typing was performed by high-resolution sequence-based typing method. Results. Our analysis revealed higher frequency of C∗07:02:01, B∗39:06:02, C∗03:02:01, B∗44:03:01, B∗51:01:05, and B∗73:01 (p
Databáze: Directory of Open Access Journals
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