Integrative analyses of hub genes and their association with immune infiltration in adipose tissue, liver tissue and skeletal muscle of obese patients after bariatric surgery

Autor:	Kemin Yan, Pengyuan Zhang, Jiewen Jin, Xin Chen, Hongyu Guan, Yanbing Li, Hai Li
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Obesity bariatric surgery adipose tissue liver tissue skeletal muscle immune cell infiltration Diseases of the endocrine glands. Clinical endocrinology RC648-665 Cytology QH573-671 Physiology QP1-981
Zdroj:	Adipocyte, Vol 11, Iss 1, Pp 190-201 (2022)
Druh dokumentu:	article
ISSN:	21623945 2162-397X 2162-3945
DOI:	10.1080/21623945.2022.2060059
Popis:	Bariatric surgery (BS) is an effective treatment for obesity. Adipose tissue, liver tissue and skeletal muscle are important metabolic tissues. This study investigated hub genes and their association with immune infiltration in these metabolic tissues of obese patients after BS by bioinformatic analysis with Gene Expression Omnibus datasets. Differentially expressed genes (DEGs) were identified, and a protein–protein interaction network was constructed to identify hub genes. As a result, 121 common DEGs were identified and mainly enriched in cytokine–cytokine receptor interactions, chemokine signaling pathway, neutrophil activation and immune responses. Immune cell infiltration analysis showed that the abundance of M1 macrophages was significantly lower in adipose and liver tissue after BS (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f96be50fde0942ce81519f367f414f4b Zobrazit plný text záznamu View record in DOAJ