The effect of follicle-stimulating hormone administration on the day of human chorionic gonadotropin trigger on assisted reproductive technique outcomes in patients undergoing In vitro fertilization-embryo transfer: A retrospective cohort study

Autor: Chithira Pulimoottil Vignarajan, Neeta Singh, Perumal Vanamail
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Human Reproductive Sciences, Vol 13, Iss 3, Pp 196-200 (2020)
Druh dokumentu: article
ISSN: 0974-1208
1998-4766
DOI: 10.4103/jhrs.JHRS_137_19
Popis: Aim: The aim is to study the effect of follicle-stimulating hormone (FSH) administration on the day of human chorionic gonadotropin (hCG) trigger on the assisted reproductive technique (ART) outcomes in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles. Settings and Design: Retrospective cohort study was conducted in the ART center of our hospital. Materials and Methods: Two hundred and ninety IVF/ICSI cycles performed between September 2012 and August 2017 were included in the study. Patients who received 375 IU of FSH on the day of hCG trigger (149 cycles) were compared with those who did not receive FSH on the day of trigger (141 cycles). Statistical Analysis Used: Chi-square test and Student's t-test were used. Results: The FSH co-administered group had a significantly higher number of oocytes retrieved, mature oocytes, and fertilization rate compared to those who did not receive FSH on the day of trigger (p < 0.001). The total number of embryos, the number of grade 1 embryos and the number of embryos available for cryopreservation were also significantly higher in the FSH administered group (p < 0.001). Implantation rate, clinical pregnancy rate, and live birth rate were not significantly different between the two groups. Conclusions: This study has shown that FSH administration on the day of the trigger may be considered in IVF cycles receiving hCG trigger to improve the oocyte recovery and maturity if the patient is not at increased risk of ovarian hyperstimulation and serum estradiol on the day of the trigger is
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