Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals

Autor: Jennifer Connors, David Joyner, Nathan J. Mege, Gina M. Cusimano, Matthew R. Bell, Jennifer Marcy, Bhavani Taramangalam, Kenneth M. Kim, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Michele A. Kutzler, Mohamad-Gabriel Alameh, Elias K. Haddad
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-023-04555-1
Popis: The role of empty lipid nanoparticles in eliciting dendritic cell maturation and innate immune signaling is shown to be impaired in older adults, potentially contributing to lower immune responses to SARS-CoV-2 mRNA-based vaccines.
Databáze: Directory of Open Access Journals
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