| Autor: |
Rena C. Patel, Patrick Oyaro, Beryne Odeny, Irene Mukui, Katherine K. Thomas, Monisha Sharma, James Wagude, Eunice Kinywa, Frederick Oluoch, Francesca Odhiambo, Boaz Oyaro, Grace C. John-Stewart, Lisa L. Abuogi |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Contemporary Clinical Trials Communications, Vol 20, Iss , Pp 100673- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2451-8654 |
| DOI: |
10.1016/j.conctc.2020.100673 |
| Popis: |
Background: As many as 40% of the 1 million children living with HIV (CLHIV) receiving antiretroviral treatment (ART) in resource limited settings have not achieved viral suppression (VS). Kenya has a large burden of pediatric HIV with nearly 140,000 CLHIV. Feasible, scalable, and cost-effective approaches to ensure VS in CLHIV are urgently needed. The goal of this study is to determine the feasibility and impact of point-of-care (POC) viral load (VL) and targeted drug resistance mutation (DRM) testing to improve VS in children on ART in Kenya. Methods: We are conducting a randomized controlled study to evaluate the use of POC VL and targeted DRM testing among 704 children aged 1–14 years on ART at health facilities in western Kenya. Children are randomized 1:1 to intervention (higher frequency POC VL and targeted DRM testing) vs. control (standard-of-care) arms and followed for 12 months. Our primary outcome is VS (VL |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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