| Autor: |
Tomoya Maeda, Akira Matsuda, Chie Asou, Daisuke Okamura, Ken Tanae, Mika Kohri, Maho Ishikawa, Naoki Takahashi, Kunihiro Tsukasaki, Nobutaka Kawai, Norio Asou, Masami Bessho |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Leukemia Research Reports, Vol 15, Iss , Pp 100231- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2213-0489 |
| DOI: |
10.1016/j.lrr.2020.100231 |
| Popis: |
To determine the impact of peripheral blood (PB) Wilms’ tumour 1 (WT-1) mRNA levels in patients with primary myelodysplastic syndromes (MDS), we analysed the relationships between several clinical variables at the time of diagnosis and the haematological response of patients treated with azacytidine. We observed overall responses in 20 (63%) patients; there were no significant differences in clinical variables, including bone marrow blast counts, IPSS scores and IPSS-R risk scores, between responders and non-responders. The responders’ PB WT-1 mRNA levels were significantly lower than those of non-responders (P = 0.03). PB WT-1 mRNA expression could be a marker for predicting the response to azacytidine in patients with de novo MDS. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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