| Autor: |
S.E. Pérez-Topete, T. Miranda-Aquino, J.A. Hernández-Portales |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Revista de Gastroenterología de México (English Edition), Vol 81, Iss 4, Pp 190-194 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2255-534X |
| DOI: |
10.1016/j.rgmxen.2016.09.003 |
| Popis: |
Introduction: Clostridium difficile (C. difficile) is a Gram-positive bacillus that is a common cause of diarrhea in the hospital environment, with a documented incidence of up to 10%. There are different methods to detect it, but a widely used test in our environment is the immunoassay for toxins A and B. Aims: The aim of our study was to 1) estimate the positive predictive value of the immunoassay for the detection of the C. difficile toxins A and B, 2) to establish the incidence of C. difficile associated diarrhea in the hospital, and 3) to know the most common associated factors. Methods: A diagnostic test accuracy study was conducted within the time frame of January 2010 to August 2013 at the Hospital Christus Muguerza® Alta Especialidad on patients with symptoms suggestive of C. difficile-associated diarrhea that had a positive immunoassay test and confirmation of C. difficile through colon biopsy and stool culture. Results: The immunoassay for toxins A and B was performed in 360 patients. Fifty-five of the cases had positive results, 35 of which showed the presence of C. difficile. Incidence was 10.2% and the positive predictive value of the test for C. difficile toxins A and B was 0.64 (95% CI, 0.51-0.76). Previous antibiotic therapy (n = 29) and proton pump inhibitor use (n = 19) were the most common associated factors. Conclusions: C. difficile incidence in our environment is similar to that found in the literature reviewed, but the positive predictive value of the test for toxin A and B detection was low. |
| Databáze: |
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| Externí odkaz: |
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