OCTA biomarkers in adults aged 50 and above: a prospective and cross-sectional community-based study

Autor: Yan Kiu Li, Nicholas Siu-Kay Fung, Jonathan C.H Chan, Bonnie N.K. Choy, Loraine L.W. Chow, Kendrick C. Shih, Jasper K.W. Wong, Ian Y.H. Wong
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BMC Ophthalmology, Vol 23, Iss 1, Pp 1-8 (2023)
Druh dokumentu: article
ISSN: 1471-2415
DOI: 10.1186/s12886-023-02815-6
Popis: Abstract Background/Aims To assess the normative values and parameters of optical coherence tomography angiography (OCTA) influencing the best corrected visual acuity (BCVA) in adults aged 50 and above. Methods This was a prospective cross-sectional study from an eye screening programme in Hong Kong for 4188 citizens aged 50 and above. Images were analysed using a validated quantification software calculating vessel density and capillary perfusion density (CPD), along with other OCTA parameters, such as the foveal avascular zone area (FAZ) and circularity. OCTA data was collected from May 2019 to December 2020, including a total of 4188 healthy eyes from 4188 subjects. Results Mean superficial vessel density (MSVD) was 14.48 ± 3.60 mm− 1, while the mean capillary perfusion density (MCPD) was 0.41 ± 0.06. Multivariate analysis revealed ageing (β = 0.321, p
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