Exosomes loaded with ultrasmall Pt nanoparticles: a novel low-toxicity alternative to cisplatin

Autor:	María Sancho-Albero, Ana Martín-Pardillos, Lluís Lujan, Víctor Sebastian, Jesús Santamaria, Pilar Martín-Duque
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Platinum nanoparticles Exosomes Cancer Extracellular vesicles Selectivity Systemic toxicity Biotechnology TP248.13-248.65 Medical technology R855-855.5
Zdroj:	Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-14 (2022)
Druh dokumentu:	article
ISSN:	1477-3155
DOI:	10.1186/s12951-022-01675-4
Popis:	Abstract Background Platinum nanoparticles have been demonstrated to have excellent anticancer properties. However, because of the lack of specificity they must be delivered to the tumor in amounts sufficient to reach the desired therapeutic objectives. Interestingly, exosomes are considered as excellent natural selective delivery nanotools, but until know their targeting properties have not being combined with the anticancer properties of platinum nanoparticles. Results In this work we combine the targeting capabilities of exosomes and the antitumoral properties of ultrasmall (
Databáze:	Directory of Open Access Journals
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