Three-dimensional iodine mapping quantified by dual-energy CT for predicting programmed death-ligand 1 expression in invasive pulmonary adenocarcinoma

Autor:	Kazuki Yamagata, Masahiro Yanagawa, Akinori Hata, Ryo Ogawa, Noriko Kikuchi, Shuhei Doi, Keisuke Ninomiya, Yukiko Tokuda, Noriyuki Tomiyama
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Dual-energy CT Extracellular volume Non-small cell lung cancer Immune checkpoint inhibitor Programmed cell death 1- ligand 1 Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-69470-9
Popis:	Abstract We examined the association between texture features using three-dimensional (3D) io-dine density histogram on delayed phase of dual-energy CT (DECT) and expression of programmed death-ligand 1 (PD-L1) using immunostaining methods in non-small cell lung cancer. Consecutive 37 patients were scanned by DECT. Unenhanced and enhanced (3 min delay) images were obtained. 3D texture analysis was performed for each nodule to obtain 7 features (max, min, median, mean, standard deviation, skewness, and kurtosis) from iodine density mapping and extracellular volume (ECV). A pathologist evaluated a tumor proportion score (TPS, %) using PD-L1 immunostaining: PD-L1 high (TPS ≥ 50%) and low or negative expression (TPS
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f910323114a94c35aa049304248c3efd Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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