Selective impact of HIV disease progression on the innate immune system in the human female reproductive tract.

Autor: Timothy Lahey, Mimi Ghosh, John V Fahey, Zheng Shen, Lucy R Mukura, Yan Song, Susan Cu-Uvin, Kenneth H Mayer, Peter F Wright, John C Kappes, Christina Ochsenbauer, Charles R Wira
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: PLoS ONE, Vol 7, Iss 6, p e38100 (2012)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0038100
Popis: We have previously demonstrated intrinsic anti-HIV activity in cervicovaginal lavage (CVL) from HIV-infected women with high CD4 counts and not on antiretroviral therapy. However, the impact of HIV disease progression on CVL innate immune responses has not been delineated.CVL from 57 HIV-infected women not on antiretroviral therapy were collected by washing the cervicovaginal area with 10 ml of sterile normal saline. We characterized subject HIV disease progression by CD4 count strata: >500 cells/µl, 200-500 cells/µl, or
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