Epithelial apical glycosylation changes associated with thin endometrium in women with infertility - a pilot observational study

Autor: Marina M. Ziganshina, Nataliya V. Dolgushina, Galina V. Kulikova, Nafisa M. Fayzullina, Ekaterina L. Yarotskaya, Nailia R. Khasbiullina, Nigora F. Abdurakhmanova, Aleksandra V. Asaturova, Alexander I. Shchegolev, Alina A. Dovgan, Gennady T. Sukhikh
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 1477-7827
DOI: 10.1186/s12958-021-00750-z
Popis: Abstract Background Low endometrial receptivity is one of the major factors affecting successful implantation in assisted reproductive technologies (ART). Infertile patients with thin endometrium have a significantly lower cumulative clinical pregnancy rate than patients with normal endometrium. Molecular pathophysiology of low receptivity of thin endometrium remains understudied. We have investigated composition of glycocalyx of the apical surface of luminal and glandular epithelial cells in thin endometrium of infertile women. Methods Thirty-two patients with tubal-peritoneal infertility undergoing in vitro fertilization (IVF) were included in the study. Endometrial samples were obtained in a natural menstrual cycle. Patients were divided into two groups: patients with normal endometrium (≥8 mm) and with thin endometrium (
Databáze: Directory of Open Access Journals
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