Vitamin d deficiency with high parathyroid hormone levels is related to late onset SEPSIS among preterm infants

Autor: I. Tofe-Valera, J. L. Pérez-Navero, J. Caballero-Villarraso, M. D. Cañete, R. Villa-Jiménez, M. J. De la Torre-Aguilar
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BMC Pregnancy and Childbirth, Vol 23, Iss 1, Pp 1-11 (2023)
Druh dokumentu: article
ISSN: 1471-2393
DOI: 10.1186/s12884-022-05334-2
Popis: Abstract Summary Preterm infants (PTs) are at greater risk for vitamin D deficiency, which relates to the possibility of a higher incidence of comorbidities. Our goal was twofold, 1) to monitor vitamin D, calcium, phosphorus, parathyroid hormone (PTH), matrix metalloproteinase-8 (MMP-8) serum levels at three-time points during hospitalization, and 2) to assess the association between 25-hydroxyvitamin D (25OHD) levels and outcomes in PTs. Methods We carried out a follow-up on 50 Caucasian PTs ≤ 32 weeks of gestational age (GA) and/or ≤ 1500 g birth weight at 28 days and at 4 months. PTs were divided into two subgroups for tests of association with clinical outcomes based on vitamin D deficient infants 25(OH) D cord blood levels: ≤ 20 ng/ml). At an initial stage, 25(OH) D levels were determined in maternal/preterm blood samples and were compared to full term delivery infants. Results There were no differences in 25(OH) D serum levels at birth when comparing PTs to term infants, or regarding maternal levels. A strong positive correlation was detected between maternal and neonatal 25(OH) D serum levels among PTs and term infants (r: 0.466; p 60 pg/mL; group 2: vitamin D > 20 and PTH
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje