| Autor: |
Sara E. Stinson, Anna E. Jonsson, Mette K. Andersen, Morten A. V. Lund, Louise Aas Holm, Cilius E. Fonvig, Yun Huang, Evelina Stankevič, Helene Bæk Juel, Lars Ängquist, Thorkild I. A. Sørensen, Emily L. Ongstad, Ranjitha Gaddipati, Joseph Grimsby, Christopher J. Rhodes, Oluf Pedersen, Michael Christiansen, Jens‐Christian Holm, Torben Hansen |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 3 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2047-9980 |
| DOI: |
10.1161/JAHA.122.027042 |
| Popis: |
Background Lectin‐like oxidized low‐density lipoprotein (ox‐LDL) receptor‐1 is a scavenger receptor for oxidized low‐density lipoprotein. In adults, higher soluble lectin‐like ox‐LDL receptor‐1 (sLOX‐1) levels are associated with cardiovascular disease, type 2 diabetes, and obesity, but a similar link in pediatric overweight/obesity remains uncertain. Methods and Results Analyses were based on the cross‐sectional HOLBAEK Study, including 4‐ to 19‐year‐olds from an obesity clinic group with body mass index >90th percentile (n=1815) and from a population‐based group (n=2039). Fasting plasma levels of sLOX‐1 and inflammatory markers were quantified, cardiometabolic risk profiles were assessed, and linear and logistic regression analyses were performed. Pubertal/postpubertal children and adolescents from the obesity clinic group exhibited higher sLOX‐1 levels compared with the population (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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