| Autor: |
Han Jo Jeon, Seung Jeong, Hyuk Soon Choi, Se Hyun Jang, Sang Hoon Kim, Seung Han Kim, Jae Min Lee, Eun Sun Kim, Bora Keum, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Jong Hoon Chung, Seong Nam Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Gut and Liver, Vol 15, Iss 2, Pp 217-224 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1976-2283 |
| DOI: |
10.5009/gnl19383 |
| Popis: |
Background/Aims: Chitosan, a natural polymer widely used in the biomaterials field, has been proposed as a potential submucosal injection solution. The purpose of this study was to compare the performance and efficacy of aqueous chitosan solution and commercialized submucosal injection fluids using a three-dimensional sensor and to evaluate the efficacy of the measured parameters. Methods: Normal saline (0.9% NaCl), as a control, Eleview® (Poloxamer 188), Blue EyeTM (0.4% hyaluronic acid), and aqueous chitosan solution (2.0%) were injected into the submucosa of porcine stomachs ex vivo. The mucosal elevation height, elevated surface area, and angle of the tangent of the submucosal fluid cushion were measured using a three-dimensional sensor. The rates of change for each variable were calculated, and the correlation between parameters was analyzed. Tissue specimens were stained with hematoxylin and eosin. Results: All variables exhibited the highest values under chitosan injection. The mucosal elevation height rate of change differed significantly between normal saline and chitosan solution (p=0.024). The elevated surface area rates of change for normal saline and Eleview® were significantly different from those for TS-905 and chitosan solution (p=0.006 and p=0.009, respectively). Further, height, area, and angle showed a positive correlation (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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