Effect of tumor necrosis factor-α inhibitors on ambulatory 24-h blood pressure

Autor: Chagai Grossman, Gil Bornstein, Avshalom Leibowitz, Ilan Ben-Zvi, Ehud Grossman
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Blood Pressure, Vol 26, Iss 1, Pp 24-29 (2017)
Druh dokumentu: article
ISSN: 0803-7051
1651-1999
08037051
DOI: 10.1080/08037051.2016.1183460
Popis: Tumor necrosis factor alpha (TNF-α) inhibitors are increasingly being used in inflammatory rheumatic diseases (IRD). The risk of cardiovascular disease is elevated in patients with IRD and TNF-α inhibitors reduce this risk. We assessed whether the beneficial effect of TNF-α inhibitors on cardiovascular risk is mediated by blood pressure reduction. We measured blood pressure levels with 24-h ambulatory blood pressure measurements device in patients with IRD before and 3 months after treatment with TNF-α inhibitors. The study population consisted of 15 subjects (6 men; mean age 45.9 ± 14.1 years). Most patients had either rheumatoid arthritis or psoriatic arthritis and adalimumab was the most common TNF-α inhibitor used. Mean 24-h systolic and diastolic blood pressure levels remained the same after treatment (121 ± 12/66 ± 7 before and 123 ± 11/67 ± 10 mm Hg after; p = 0.88 and 0.66, respectively). The study demonstrates that TNF-α inhibitors have no effect on blood pressure levels.
Databáze: Directory of Open Access Journals
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