Effects of Intravenous Ondansetron and Granisetron on Haemodynamic Changes during Spinal Anaesthesia in Non-obstetric Population: A Randomised Double-blind Study
| Autor: | Srihari Bommala, Madhusudan Mukkara, Aloka Samantaray, Hemalatha Pasupuleti, Dyva Manogna Reddycogu, Santhi Swetha Pudotha, Shravani Pabba, Sathish |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 13, Iss 5, Pp UC01-UC04 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2019/41121.12830 |
| Popis: | Introduction: Two commonly used antiemetics in the perioperative period may attenuate the spinal anaesthesia induced hypotension by attenuating the Bezold-Jarisch Reflex (BJR). Aim: To evaluate and compare the efficacy of intravenous administration of ondansetron and granisetron five minutes prior to spinal anaesthesia on incidence of spinal anaesthesia induced hypotension and bradycardia. Materials and Methods: Ninety patients scheduled for elective infraumbilical non-obstetric surgeries under spinal anaesthesia were enrolled for the study, after obtaining written informed consent. Patients were randomised to receive 4 mg ondansetron (group O), 1 mg granisetron (group G) or normal saline (control group) intravenously, five minutes prior to spinal anaesthesia. Changes in haemodynamics were noted after spinal anaesthesia to identify the number of episodes of hypotension and bradycardia necessitating treatment with ephedrine, atropine or both. The obtained data was analysed with one-way ANOVA or Chi-square test with post-hoc comparison to find out pairwise difference. Statistical significance was considered as p |
| Databáze: | Directory of Open Access Journals |
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