| Autor: |
Zai-Shang Li, Antonio Augusto Ornellas, Christian Schwentner, Xiang Li, Alcides Chaux, Georges Netto, Arthur L. Burnett, Yong Tang, JiunHung Geng, Kai Yao, Xiao-Feng Chen, Bin Wang, Hong Liao, Nan Liu, Peng Chen, Yong-Hong Lei, Qi-Wu Mi, Hui-Lan Rao, Ying-Ming Xiao, Qi-Lin Wang, Zi-Ke Qin, Zhuo-Wei Liu, Yong-Hong Li, Zi-Jun Zou, Jun-Hang Luo, Hui Li, Hui Han, Fang-Jian Zhou |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Cancer Communications, Vol 38, Iss 1, Pp 1-10 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2523-3548 |
| DOI: |
10.1186/s40880-018-0340-x |
| Popis: |
Abstract Background The 8th American Joint Committee on Cancer tumor–node–metastasis (AJCC-TNM) staging system is based on a few retrospective single-center studies. We aimed to test the prognostic validity of the staging system and to determine whether a modified clinicopathological tumor staging system that includes lymphovascular embolization could increase the accuracy of prognostic prediction for patients with stage T2–3 penile cancer. Methods A training cohort of 411 patients who were treated at 2 centers in China and Brazil between 2000 and 2015 were staged according to the 8th AJCC-TNM staging system. The internal validation was analyzed by bootstrap-corrected C-indexes (resampled 1000 times). Data from 436 patients who were treated at 15 centers over four continents were used for external validation. Results A survivorship overlap was observed between T2 and T3 patients (P = 0.587) classified according to the 8th AJCC-TNM staging system. Lymphovascular embolization was a significant prognostic factor for metastasis and survival (all P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Full text from SpringerLink