| Autor: |
Luís Correia Gomes, Bernardo Alves Pereira, Isália Miguel, Ana Luís, Ana Pina, Cátia Pedro, Daniela Cavadas, Daniela Pereira, Joana Lemos, João Maciel, João Oliveira, José Venâncio, Madalena Santos, Manuel Limbert, Miguel Braga, Miriam Abdulrehman, Pedro Freitas, Ricardo Fonseca, Teresa Ferreira, Isadora Rosa |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-10 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1477-7819 |
| DOI: |
10.1186/s12957-024-03590-4 |
| Popis: |
Abstract Background Locally advanced rectal cancer (LARC) poses a significantly challenge in clinical management, requiring a multimodal treatment approach. Among innovative strategies, Total Neoadjuvant Therapy (TNT) has emerged, delivering all planned chemotherapy before surgery. Objective Our aim was to evaluate the real-world application and efficacy of TNT and to compare it with the non-TNT standard strategy. Methods This retrospective study compared locally advanced rectal adenocarcinoma patients treated with Total Neoadjuvant Therapy (TNT) in 2022 with those who underwent traditional chemoradiotherapy (CRT) in 2020–2021. The primary endpoints were the pathologic complete response rate and the sustained clinical complete response rate in patients under W&W. Results Among 107 patients (54.2% male, mean age 62.48 years), non-TNT (67 patients) and TNT (40 patients) mean follow-ups were 26.7 and 8.2 months, respectively. No differences in gender(p = 0.163), staging (p = 0.707), or location (p = 0.727) were noted. TNT patients received more short-course radiotherapy (42.5% vs1.5%, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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