Prochloraz induced alterations in the expression of mRNA in the reproductive system of male offspring mice

Autor: Junhe Hu, Chang Liu, Xianghui Zeng, Tao Tang, Zhi Zeng, Juan Wu, Xiansheng Tan, Qingxiang Dai, Chenzhong Jin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: PeerJ, Vol 12, p e17917 (2024)
Druh dokumentu: article
ISSN: 2167-8359
DOI: 10.7717/peerj.17917
Popis: Prochloraz is a widely used fungicide worldwide. It is classified as an endocrine disrupting pesticide that affects the reproductive system. This study aimed to examine the impact of exposure to prochloraz of male mice on the reproductive system of their offspring male mice. Male father mice were intragastrically administered different dosages of prochloraz (group MA: 0 mg/kg/day; MB: 53.33 mg/kg/day; MD:160 mg/kg/day). Then, the testicular average weight of male offspring in the dose groups was found to be significantly lower than those in the control group (MB:0.312g, MD:0.294g, and MA:0.355 g; P
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