Acute myeloid leukemia and NK cells: two warriors confront each other

Autor:	Aroa Baragaño Raneros, Carlos López-Larrea, Beatriz Suárez-Álvarez
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	acute myeloid leukemia natural killer cells nkg2d car-t immunotherapy immune checkpoints Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 8, Iss 2 (2019)
Druh dokumentu:	article
ISSN:	2162-402X 2162402X
DOI:	10.1080/2162402X.2018.1539617
Popis:	Acute myeloid leukemia (AML) is a heterogeneous disease whose therapies currently show elevated toxicity and a high rate of relapse. Recently, the burgeoning of new anti-tumor therapeutic strategies aimed at enhancing the immune response has pushed natural killer cells (NKs) into the spotlight. These cells are powerful warriors that can bring about the lysis of tumor cells through their cytotoxic ability. However, tumor cells have developed strategies to evade recognition mediated by NKs. Here, we review the mechanisms triggered by AML cells and discuss the emerging immunotherapeutic strategies that potentiate the anti-tumor functions of NKs.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ef89548a3bb047768200302b1b59fa08 Zobrazit plný text záznamu View record in DOAJ