| Autor: |
MARIA AYALA VALVERDE, Jorge Arnold Alvarez, Gustavo Ayares, Francisco Barrera, Daniel Cabrera, Luis Antonio Diaz, Juan Pablo Arab, Ibon Martinez-Arranz, Cristina Alonso, Jesús M. Bañales, Marco Arrese |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Annals of Hepatology, Vol 29, Iss , Pp 101605- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1665-2681 |
| DOI: |
10.1016/j.aohep.2024.101605 |
| Popis: |
Conflict of interest: Yes, Fondecyt # 1241450 Introduction and Objectives: Background: There is limited information on features of lean MASLD patients in Latino subjects. We aimed to analyze the features of MASLD in Chilean patients with normal body mass index (BMI), the frequency of the rs738409 risk polymorphism (PNPLA3 I148M variant) and metabolomic profiles in Chilean individuals with MASLD. Patients / Materials and Methods: A cross-sectional study involving 181 randomly-selected participants diagnosed with MASLD from the prospective Maule Cohort (BMC Public Health. 2016;16:122). Participants were categorized into lean, overweight, and obese groups based on their BMI. The presence of the rs738409 polymorphism was examined using Sanger sequencing. Metabolomics was assessed using UHPLC-MS in a separate group of biopsy-proven MASLD patients. Statistical analyses of clinical data and genotypes encompassed Fisher's exact test, Chi-square test, Kruskal-Wallis test. Results and Discussion: 31.49% (57) were classified as thin, 36.3% (61) as overweight and 39.8% (67) as obese. Higher ALT levels (p=0.004) and body fat percentage in obese subjects were the only significant differences found among the groups. The allelic frequency of rs738409 was similar among groups 77.1%, 83.6% and 82.5% in lean, overweight, and obese subjects, respectively (n.s.). Circulating metabolome showed increased levels of ceramides in overweight and obese patients compared to lean subjects (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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