| Autor: |
Stefan Fischer, Michael J. Rynkiewicz, Jeffrey R. Moore, William Lehman |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Structural Dynamics, Vol 3, Iss 1, Pp 012002-012002-11 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2329-7778 |
| DOI: |
10.1063/1.4940223 |
| Popis: |
Coiled-coil tropomyosin binds to consecutive actin-subunits along actin-containing thin filaments. Tropomyosin molecules then polymerize head-to-tail to form cables that wrap helically around the filaments. Little is known about the assembly process that leads to continuous, gap-free tropomyosin cable formation. We propose that tropomyosin molecules diffuse over the actin-filament surface to connect head-to-tail to partners. This possibility is likely because (1) tropomyosin hovers loosely over the actin-filament, thus binding weakly to F-actin and (2) low energy-barriers provide tropomyosin freedom for 1D axial translation on F-actin. We consider that these unique features of the actin-tropomyosin interaction are the basis of tropomyosin cable formation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
