Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems

Autor: Abdolhossien Massoudi, Mohsen Adeli, Leila Khosravi far
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: International Journal of Polymer Science, Vol 2014 (2014)
Druh dokumentu: article
ISSN: 1687-9422
1687-9430
DOI: 10.1155/2014/829474
Popis: Pseudopolyrotaxanes (PPR) consisting of α-cyclodextrin rings and polyethylene glycol axes with end thymine groups have been synthesized and characterized successfully. Fluorescein (Fl) as a model drug was conjugated to the hydroxyl functional groups of cyclodextrin rings of PPR via ester bonds and PPR-Fl as the primary drug delivery system was obtained. Finally PPR-Fl was capped by hydrogen bonds between end thymine groups and a suitable complementary molecule such as polycitric acid, citric acid, or adenine. The aim of this work was to control the release of the fluorescein-cyclodextrin (Fl-CD) conjugates, as the secondary drug delivery systems, from PPR-Fl by controlling the noncovalent interactions between stoppers and thymine end groups. It was found that the rate of release of the Fl-CD from PPR-Fl could be controlled by pH and the ratio of citric acid or adenine to the PPR-Fl.
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