The hijacking of HBV by small extracellular vesicles inhibits M1 macrophages to facilitate immune evasion

Autor:	Zili Zhang, Jiamin Liu, Ling Yu, Rong Zeng, Wanlong Pan
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Small extracellular vesicles M1 macrophages MiR-146a FEN-1 Immune evasion Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-70924-3
Popis:	Abstract Small extracellular vesicles (sEVs) have the ability to transfer genetic material between cells, but their role in mediating HBV infection and regulating M1 macrophages to promote immune evasion remains unclear. In this study, we utilized PMA + LPS + IFN-γ to induce THP-1 into M1 macrophages. We then extracted sEVs from HepG2.2.15 cell and treated the M1 macrophages with these sEVs. QPCR detection revealed the presence of HBV-DNA in the M1 macrophages. Additionally, RT-qPCR and WB analysis demonstrated a significantly decreased in the expression of TLR4, NLRP3, pro-caspase-1, caspase-1p20, IL-1β and IL-18 in the M1 macrophages (P
Databáze:	Directory of Open Access Journals
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