Expression of SET Protein in the Ovaries of Patients with Polycystic Ovary Syndrome
| Autor: | Xu Boqun, Dai Xiaonan, Cui YuGui, Gao Lingling, Dai Xue, Chao Gao, Diao Feiyang, Liu Jiayin, Li Gao, Mei Li, Yuan Zhang, Xiang Ma |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | International Journal of Endocrinology, Vol 2013 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1687-8337 1687-8345 |
| DOI: | 10.1155/2013/367956 |
| Popis: | Background. We previously found that expression of SET gene was up-regulated in polycystic ovaries by using microarray. It suggested that SET may be an attractive candidate regulator involved in the pathophysiology of polycystic ovary syndrome (PCOS). In this study, expression and cellular localization of SET protein were investigated in human polycystic and normal ovaries. Method. Ovarian tissues, six normal ovaries and six polycystic ovaries, were collected during transsexual operation and surgical treatment with the signed consent form. The cellular localization of SET protein was observed by immunohistochemistry. The expression levels of SET protein were analyzed by Western Blot. Result. SET protein was expressed predominantly in the theca cells and oocytes of human ovarian follicles in both PCOS ovarian tissues and normal ovarian tissues. The level of SET protein expression in polycystic ovaries was triple higher than that in normal ovaries (P |
| Databáze: | Directory of Open Access Journals |
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