Retinal Nerve Fibre Layer and Ganglion Cell Complex Measurement and their Correlation with Visual Field Changes among Glaucoma Patients

Autor: Kanika Yadav, Rakesh Porwal, Praveena
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Clinical and Diagnostic Research, Vol 16, Iss 6, Pp NC06-NC10 (2022)
Druh dokumentu: article
ISSN: 2249-782X
0973-709X
DOI: 10.7860/JCDR/2022/52449.16440
Popis: Introduction: Glaucoma is an optic neuropathy that causes loss of Retinal Ganglion Cell (RGC) and changes in the visual field. The loss in RGC is determined by Optical Coherence Tomography (OCT), and visual field defects are evaluated with perimetry. A study of RGC loss and visual field defects together might help to detect glaucoma earlier. Aim: To determine the relationship between Retinal Nerve Fibre Layer (RNFL) and Ganglion Cell Complex (GCC) thickness measured with OCT, and visual field sensitivity evaluated with Standard Automated Perimetry (SAP) in glaucoma patients of varying severity. Materials and Methods: This was a cross-sectional study, conducted in a tertiary care hospital, Ajmer, Rajasthan from October 2018 to January 2020. Sixty glaucoma patients were recruited for ophthalmic evaluation. The two test SAP and SD-OCT were performed on all patients. Patients were categorised into three groups i.e., early, moderate and severe, based on severity. The RNFL, Mean Deviation (MD) and Pattern Standard Deviation (PSD) were compared among these three groups. One way Analysis of Variance (ANOVA) was used to compare the mean values of RNFL, GCC, MD and PSD across the three glaucoma groups. Post hoc analysis was done by Tukey’s range test. Correlation was assessed using Spearman’s correlation coefficient. Results: The mean (SD) age of participants were 54.43 (10.07) years. Total 15% of patients belonged to early stage glaucoma, 40% to moderate and 45% to severe glaucoma. The difference in mean RNFL (both superior and inferior) was found significant among the three groups. In bivariate analysis, MD was found significantly correlated with superior and inferior RNFL (r=0.70, p-value
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