IL-6 174 G/C Polymorphism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
| Autor: | Danyal Imani, Ramazan Rezaei, Davood Jafari, Bahman Razi, Shahab Alizadeh, Mohammad Bashashati, Nima Rezaei |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Acta Medica Iranica, Vol 56, Iss 12 (2019) |
| Druh dokumentu: | article |
| ISSN: | 0044-6025 1735-9694 |
| Popis: | The results of previous studies on the association between IL-6-174G/C (rs1800795) polymorphism and inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC) are not consistent. The present meta-analysis has pooled all eligible studies to understand the relation between this gene polymorphism and IBD risk. A structured search of Medline, EMBASE, and Scopus databases were performed to identify all eligible studies published before June 2017. Odds ratio (OR) and 95% confidence intervals (CIs) were assessed applying fixed- or random-effect models to evaluate the strength of association in recessive model, dominant model, allelic model, heterozygote contrast, and homozygotes contrast. A sum of 9 articles with 1524 IBD cases and 1586 healthy subjects were included in this study. No significant association between the IL-6 -174 G/C polymorphism and overall IBD susceptibility in any tested genetic model was found. Moreover, in the subgroup analysis based on subtypes, the associations between the IL-6 174-G/C polymorphism and CD and UC missed statistical significance. The current meta-analysis suggests that the IL-6-174 G/C polymorphism is not associated with IBD susceptibility. Further and comprehensive studies are necessary to warrant this result. |
| Databáze: | Directory of Open Access Journals |
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