| Autor: |
Patricia Momoyo Yoshimura Zitelli, Michele Gomes-Gouvêa, Daniel F. Mazo, Julio da Motta Singer, Claudia P.M.S. Oliveira, Alberto Queiroz Farias, João Renato Pinho, Ryan Yukimatsu Tanigawa, Venâncio Avancini Ferreira Alves, Flair José Carrilho, Mário Guimarães Pessoa |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Clinics, Vol 76 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1980-5322 |
| DOI: |
10.6061/clinics/2021/e3270 |
| Popis: |
OBJECTIVES: Co-infection with hepatitis A or B viruses may aggravate liver injury in patients infected with hepatitis C virus (HCV). However, few studies have assessed co-infection with hepatitis E virus (HEV) and HCV. Therefore, this study aimed to assess the prevalence and impact of HEV infection among Brazilian patients with chronic HCV infection. METHODS: This observational study included adult patients with chronic HCV infection who were naive to antiviral therapy from January 2013 to March 2016. A total of 181 patients were enrolled, and HEV serology and PCR were performed for all patients. RESULTS: Seropositivity for anti-HEV IgG was detected in 22 (12.0%) patients and anti-HEV immunoglobulin M in 3 (1.6%). HEV RNA showed inconclusive results in nine (4.9%) patients and was undetectable in the remaining patients. HEV serology positive patients had more severe liver disease, characterized by liver fibrosis ≥3 versus ≤2 (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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