Acute Efavirenz Intoxication in a 16-year-old HIV Negative Girl: A Case Report and Literature Review

Autor:	Minoo Moghimi, Zahra Nekoukar, Navid Khosravi
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	efavirenz intoxication neurotoxicity human immunodeficiency virus toxicology Therapeutics. Pharmacology RM1-950
Zdroj:	Pharmaceutical and Biomedical Research, Vol 10, Iss 1, Pp 73-78 (2024)
Druh dokumentu:	article
ISSN:	2423-4494
Popis:	Background: There are only rare case reports that revealed the efavirenz (EFV) toxicity. Case Report: This study presents an acute intoxication with 12 g of efavirenz in a 16-year-old healthy girl whose main problem was dose-dependent neurotoxicity. No other serious EFV-related side effects were seen. Previous serious side effects of EFV were observed in HIV-infected patients who underwent long-term combination drug therapy. Conclusion: Accordingly, in terms of the key clinical messages, serious adverse effects of efavirenz are expected to be observed in long-term use in combination with other antiretroviral drugs.
Databáze:	Directory of Open Access Journals
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