| Autor: |
Rasmus D Wollenberg, Søren S Donau, Manuel H Taft, Zoltan Balázs, Sven Giese, Claudia Thiel, Jens L Sørensen, Thorbjørn T Nielsen, Henriette Giese, Dietmar J Manstein, Reinhard Wimmer, Teis E Sondergaard |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 15, Iss 6, p e0235568 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0235568 |
| Popis: |
Filamentous fungi belonging to the genus Fusarium are notorious plant-pathogens that infect, damage and contaminate a wide variety of important crops. Phenamacril is the first member of a novel class of single-site acting cyanoacrylate fungicides which has proven highly effective against important members of the genus Fusarium. However, the recent emergence of field-resistant strains exhibiting qualitative resistance poses a major obstacle for the continued use of phenamacril. In this study, we synthesized novel cyanoacrylate compounds based on the phenamacril-scaffold to test their growth-inhibitory potential against wild-type Fusarium and phenamacril-resistant strains. Our findings show that most chemical modifications to the phenamacril-scaffold are associated with almost complete loss of fungicidal activity and in vitro inhibition of myosin motor domain ATPase activity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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