Ceramide from sphingomyelin hydrolysis induces neuronal differentiation, whereas de novo ceramide synthesis and sphingomyelin hydrolysis initiate apoptosis after NGF withdrawal in PC12 Cells

Autor:	Terri Kagan, Gloria Stoyanova, Richard A. Lockshin, Zahra Zakeri
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Cell death Apoptosis Sphingomyelin Ceramide Nerve growth factor Medicine Cytology QH573-671
Zdroj:	Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-13 (2022)
Druh dokumentu:	article
ISSN:	1478-811X
DOI:	10.1186/s12964-021-00767-2
Popis:	Plain English summary Ceramide and sphingomyelin reportedly are important both for differentiation of nerve cells and for their death. We studied PC12 cells, which can differentiate into neuron-like cells in the presence of nerve growth factor and cells that overexpress receptors for nerve growth factor. By combining various inhibitors, we conclude that in the presence of nerve growth factor ceramide comes from hydrolysis of sphingomyelin, but when nerve growth factor is removed and the cells atrophy and die, sphingomyelin comes from both neosynthesis and hydrolysis.
Databáze:	Directory of Open Access Journals
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