Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease
| Autor: | Magali de Bruyn, Christine Breynaert, Ingrid Arijs, Gert De Hertogh, Karel Geboes, Greet Thijs, Gianluca Matteoli, Jialiang Hu, Jo Van Damme, Bernd Arnold, Marc Ferrante, Séverine Vermeire, Gert Van Assche, Ghislain Opdenakker |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 83337903 |
| DOI: | 10.1038/ncomms15384 |
| Popis: | Metalloproteinase-9 has been suggested as therapeutic target to treat inflammatory bowel disease. Here de Bruynet al. show that genetic and pharmacological inhibition of metalloproteinase-9 does not ameliorate inflammation and fibrosis in mice challenged with acute and chronic colitis protocols. |
| Databáze: | Directory of Open Access Journals |
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