The Extraordinary Case of a Woman with a 30-Year-Long Diffuse Leishmaniasis Cured with One Single Ampoule of Intranasal Pentavalent Antimoniate
| Autor: | Sheila V. C. B. Gonçalves, Dorcas L. Costa, João da J. Cantinho-Junior, José N. Vieira-Junior, Edna A. Y. Ishikawa, Rubens N. Costa, Antônio C. G. Costa-Filho, Ronald da C. Araújo, Silvia R. B. Uliana, Jenicer K. U. Y. Yasunaka, Adriano C. Coelho, Jackson M. L. Costa, Carlos H. N. Costa |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Pathogens, Vol 12, Iss 7, p 890 (2023) |
| Druh dokumentu: | article |
| ISSN: | 12070890 2076-0817 |
| DOI: | 10.3390/pathogens12070890 |
| Popis: | Infection with Leishmania amazonensis and L. mexicana may lead to diffuse cutaneous leishmaniasis. The cure is exceptional, especially for the strange case of this lady. Case report: The patient acquired the disease in childhood and remained with lesions for over 30 years, albeit several treatments. She worsened after a pregnancy, developing disseminated lesions. Miltefosine with amphotericin B and pentamidine resulted in remission. Lesions reappeared after one year, accompanied by intra-nasal infiltration of the disease. The nasal spraying of a single ampoule of pentavalent antimoniate resulted in the sustained disappearance of the nasal symptoms and all the cutaneous lesions. After over eight years, she remains disease-free, albeit under renal replacement therapy. The high nasal mucosal antimonial concentration may explain the long-lasting cure via new MHC class I epitope-specific CD8+ cell clones against L. amazonensis present in the nasal mucosa. |
| Databáze: | Directory of Open Access Journals |
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