Genotoxicity of aluminium oxide, iron oxide, and copper nanoparticles in mouse bone marrow cells

Autor: Sadiq Rakhshinda, Khan Qaiser Mahmood, Mobeen Ameena, Shah Asma
Jazyk: English<br />Croatian
Rok vydání: 2021
Předmět:
Zdroj: Arhiv za Higijenu Rada i Toksikologiju, Vol 72, Iss 4, Pp 315-325 (2021)
Druh dokumentu: article
ISSN: 1848-6312
DOI: 10.2478/aiht-2021-72-3578
Popis: The aim of this study was to evaluate the genotoxic effects of Al2O3, Fe2O3, and Cu nanoparticles with chromosomal aberration (CA), micronucleus (MN), and comet assays on the bone marrow of male BALB/c mice. Three doses of Al2O3, Fe2O3 (75, 150, and 300 mg/kg), or Cu (5, 10, and 15 mg/kg) nanoparticles were administered to mice through intraperitoneal injection once a day for 14 days and compared with negative control (distilled water) and positive control (mitomycin C and methyl methanesulphonate). Al2O3 and Fe2O3 did not show genotoxic effects, but Cu nanoparticles induced significant (P
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