| Autor: |
Federica Mangione, Enrique Martín-Blanco |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Cell Reports, Vol 25, Iss 10, Pp 2836-2850.e4 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2211-1247 |
| DOI: |
10.1016/j.celrep.2018.11.036 |
| Popis: |
Summary: The achievement of the final form of an individual requires not only the control of cell size and differentiation but also integrative directional cues to instruct cell movements, positions, and orientations. In Drosophila, the adult epidermis of the abdomen is created de novo by histoblasts. As these expand and fuse, they uniformly orient along the anteroposterior axis. We found that the Dachsous/Fat/Four-jointed (Ds/Ft/Fj) pathway is key for their alignment. The refinement of the tissue-wide expression of the atypical cadherins Ds and Ft result in their polarization and directional adhesiveness. Mechanistically, the axially oriented changes in histoblasts respond to the redesign of the epithelial field. We suggest that the role of Ds/Ft/Fj in long-range oriented cell alignment is a general function and that the regulation of the expression of its components will be crucial in other morphogenetic models or during tissue repair. : Mangione and Martín-Blanco uncover the emergence of a uniform pattern of axially oriented cells in the Drosophila abdominal epithelium. This process is spatially and temporally regulated by gradients of activity of the atypical cadherins Dachsous and Fat along the anteroposterior axis. Keywords: Drosophila, Ds/Ft/Fj pathway, planar cell polarity, axial orientation, cells alignment |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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