| Autor: |
Santosh Kumar Sharma, Amar Nath Chatterjee, Fahad Al Basir |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Results in Control and Optimization, Vol 11, Iss , Pp 100234- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2666-7207 |
| DOI: |
10.1016/j.rico.2023.100234 |
| Popis: |
Pathogen and human host interaction dynamics are often more complicated in the presence of co-pathogens. Co-infection can occur either as the presence of pre-existing pathogen which is accelerated by the new pathogen and more complications happened. In this study, we look at the burden of HIV/HCV viremia and the efficacy of treatment in reducing the severity of HIV/HCV co-infection patterns. Disease-free equilibrium and endemic equilibrium are two equilibrium states determined in the absence of drugs. The basic reproduction number is computed and the stability of the disease-free equilibrium of the model is analyzed using it. Here we have also incorporated the optimal drug therapy to control the co-infection disease progression. The efficacy of treatment has also been found to influence the natural progression of HCV in HIV/HCV co-infection. The numerical results suggest that the HIV viral load impacts the severity of the HCV infection impressively. This research is significant to develop antiviral therapy strategies to control HIV/HCV co-infection. The most effective way to control the co-infection with the minimum side effects is to take the combination of three medications with optimal dosing. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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