| Autor: |
Maryam Fotoohi, Nasrin Hadi, Faezeh Namazi |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Research in Molecular Medicine, Vol 2017, Pp 1-8 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2322-1348 |
| DOI: |
10.18502/rmm.v6i4.4800 |
| Popis: |
Background: The most malignant form of infiltrating astrocytoma, glioblastoma multiforme (GBM), is one of the most aggressive human cancers. Foretinib diminished GBM cell invasion by downregulating the expression of matrix metalloproteinase 2 (MMP2).The study aimed to examine the anti-tumor activity of foretinib and to test its effect on MMP2 expression in T98 cells.Materials and Methods: T98 cells were used as an experimental model of glioblastoma. The effect of foretinib on the expression of MMP2 was evaluated using quantitative real-time polymerase chain reaction. Thereafter, the effect of foretinib on the enzyme levels of MMP was examined by zymography. Statistical analyses were performed with GraphPad Prism software.Results: A reduction in the expression of MMP2 was observed with an increase in the concentration of foretinib.Conclusion: Foretinib treatment leads to downregulation of MMP-2 and has a positive effect on T98 cells. We believe that foretinib can be subjected to further clinical investigation to develop a treatment for GBM. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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