Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome

Autor: Xiaomin Liu, Xin Tong, Jie Zhu, Liu Tian, Zhuye Jie, Yuanqiang Zou, Xiaoqian Lin, Hewei Liang, Wenxi Li, Yanmei Ju, Youwen Qin, Leying Zou, Haorong Lu, Shida Zhu, Xin Jin, Xun Xu, Huanming Yang, Jian Wang, Yang Zong, Weibin Liu, Yong Hou, Huijue Jia, Tao Zhang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Cell Discovery, Vol 7, Iss 1, Pp 1-16 (2021)
Druh dokumentu: article
ISSN: 2056-5968
DOI: 10.1038/s41421-021-00356-0
Popis: Abstract The oral microbiota contains billions of microbial cells, which could contribute to diseases in many body sites. Challenged by eating, drinking, and dental hygiene on a daily basis, the oral microbiota is regarded as highly dynamic. Here, we report significant human genomic associations with the oral metagenome from more than 1915 individuals, for both the tongue dorsum (n = 2017) and saliva (n = 1915). We identified five genetic loci associated with oral microbiota at study-wide significance (p
Databáze: Directory of Open Access Journals