Earlier is better when treating rheumatoid arthritis: but can we detect a window of opportunity?

Autor: Cornelia F Allaart, Tom W J Huizinga, Sytske Anne Bergstra, Yvonne P M Goekoop-Ruiterman, Willem Lems, Naghmeh Riyazi, Pit J S M Kerstens, Joy A van der Pol
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: RMD Open, Vol 6, Iss 1 (2020)
Druh dokumentu: article
ISSN: 2056-5933
DOI: 10.1136/rmdopen-2020-001242
Popis: Objectives The window of opportunity (WOO) hypothesis suggests a limited time frame to stop rheumatoid arthritis (RA). We hypothesised that a WOO could either be represented by a hyperbolic (‘curved’) decline in the chance to achieve the outcome sustained drug-free remission (sDFR) over time, after which achieving sDFR is not possible anymore, or by a more gradual linear decline approaching zero chance to achieve sDFR.Methods Patients with RA (symptom duration
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