Effect of Andrographolide Extract on Blood Glucose and Lipid Profile in Rats with Secondary Iron Overload
| Autor: | َArash Mehri Pirayvatlo, Reza Alipanah-Moghadam, Mohammad Mazani, Farideh Manafi, Vadood Malekzadeh, Ali Nemati, Abbas Naghizadeh Baghi |
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| Jazyk: | perština |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Journal of Ardabil University of Medical Sciences, Vol 16, Iss 4, Pp 399-408 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2228-7280 2228-7299 |
| Popis: | Background & objectives: Iron overload is involved in the pathophysiology of many diseases including diabetes. In fact, the excess iron by creating free radicals makes damage to pancreas and leads to insulin resistance and diabetes. Andrographolide extract has hypoglycemic and antioxidant properties. This study has surveyed the effects of andrographolide on blood glucose and lipid profile in rats with secondary iron overload. Methods: In this experimental study, 36 male Wistar rats were randomly divided into 6 groups: the healthy control group, secondary iron overload group, secondary iron overload groups treated with a dose of 3.5 and 7 mg/kg of andrographolide extract, and andrographolide groups treated with a dose of 3.5 and 7 mg/kg of extract. Iron and extract were injected for 6 and 12 days, respectively. Blood samples were taken for measurement of blood glucose and lipid profiles. Data were analyzed using ANOVA test. Results: The pathological results of samples from liver of animals receiving iron showed that the iron was deposited in the liver tissues. Iron injection significantly increased blood glucose levels compared to healthy control group (p |
| Databáze: | Directory of Open Access Journals |
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