Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase

Autor: Chinnu Rose Joseph, Sabrina Dusi, Michele Giannattasio, Dana Branzei
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30215-9
Popis: Joseph et al. reveal that monoSUMOylated DDK kinase, implicated in replication initiation, acts with Rad51 recombinase to prevent replication fork uncoupling and to mediate recombination-dependent gap-filling in the presence of genotoxic stress.
Databáze: Directory of Open Access Journals