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Shao-Hua Hu,1,2 Hong Feng,3,4 Ting-Ting Xu,3,5 Hao-Rong Zhang,6 Zhi-Yong Zhao,6 Jian-Bo Lai,1,2 Dong-Rong Xu,7 Yi Xu1,2 1Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 2The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, 3Faculty of Clinical Medicine, Zhejiang University School of Medicine, Hangzhou, 4Department of Psychiatry, Shaoxing No Seven People’s Hospital, Shaoxing, 5Department of Psychiatry, The Center of Mental Health, Xiaoshan Hospital, Hangzhou, 6Shanghai Key Laboratory of Magnetic Resonance, Key Laboratory of Brain Function Genomics, East China Normal University, Shanghai, China; 7Epidemiology Division and MRI Unit, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA Objective: Structural studies have reported anorexia nervosa (AN) patients with abnormal gray matter in several brain regions and dysfunction in some connected neural circuits. However, the role of white matter (WM) in AN patients has rarely been investigated. The present study aimed to assess alterations in WM microstructure of the entire brain in females with AN using a voxel-based method on diffusion tensor imaging (DTI) data.Materials and methods: The study enrolled 8 female patients with AN and 14 age-matched females as controls (CW). The DTI data was collected from each subject to calculate the fractional anisotropy (FA) maps of the whole brain by the DTI-Studio software. Subsequently, a 2-sample t-test (P |
