Heterogeneous response of estimated insulin sensitivity indices to metformin in young individuals with type 1 diabetes and different phenotypes

Autor:	Luana A. L. Ramaldes, Sarah S. dos Santos, Patricia M. Dualib, Joao R. de Sa, Sérgio A. Dib
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Insulin resistance Type 1 diabetes mellitus Obesity Metformin Nutritional diseases. Deficiency diseases RC620-627
Zdroj:	Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-9 (2024)
Druh dokumentu:	article
ISSN:	1758-5996
DOI:	10.1186/s13098-024-01451-4
Popis:	Abstract Aims This study aimed to investigate whether the response to adding metformin to insulin in young adults with type 1 diabetes (T1D) differs according to weight phenotype and insulin sensitivity index. Methods A prospective pilot study was conducted over 26 weeks in which insulin plus metformin (2 g/day) was administered to 35 individuals, ranging from normal weight (NW) to overweight (OW) to obese (OB) T1D individuals, to correlate insulin sensitivity indices and other clinical variables. Results At the end of the follow-up period, all groups showed an increase in the eGDR (NW: 7.37 vs 8.16, p = 0.002; OW: 7.28 vs 8.24, p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f7d3de3f87e1486ca842a731d840c0c8 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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