HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells
| Autor: | Feixin Liang, Shinichiro Kina, Hiroyuki Takemoto, Akira Matayoshi, Thongsavanh Phonaphonh, Nao Sunagawa, Keiichi Arakaki, Akira Arasaki, Hai Kuang, Hajime Sunakawa |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Mediators of Inflammation, Vol 2011 (2011) |
| Druh dokumentu: | article |
| ISSN: | 0962-9351 1466-1861 |
| DOI: | 10.1155/2011/263216 |
| Popis: | To date, the major role of HPV16E6 in cancer has been considered to be its ability to inhibit the p53 tumor-suppressor protein, thereby thwarting p53-mediated cytotoxic responses to cellular stress signals. Here, we show that HPV16E6-dependent c-fos oncogenic protein expression contributes to AP-1 complex formation under oxidative stress in SiHa cells (HPV16-positive squamous cell carcinoma of the cervix). In addition, we examined the role of HPV16E6 in TGF-α-induced c-fos expression and found that the c-fos protein expression induced by TGF-α is HPV16E6 dependent. Thus, our results provide the first evidence that HPV16E6 contributes to AP-1 complex formation after both ligand-dependent and independent EGFR activation, suggesting a new therapeutic approach to the treatment of HPV-associated tumors. |
| Databáze: | Directory of Open Access Journals |
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