Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy

Autor:	Ghaleb Goussous, Sadaf Jafferbhoy, Niamh Smyth, Lisette Hammond, Sankaran Narayanan, Robert Mark Kirby, Soni Soumian
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	International Journal of Breast Cancer, Vol 2017 (2017)
Druh dokumentu:	article
ISSN:	2090-3170 2090-3189
DOI:	10.1155/2017/4971096
Popis:	One-step nucleic acid amplification (OSNA) is an intraoperative technique with a high sensitivity and specificity for sentinel node assessment. The aim of this study was to assess the impact of OSNA on micrometastases detection rates and use of adjuvant chemotherapy. A retrospective review of patients with sentinel node micrometastases over a five-year period was carried out and a comparison of micrometastases detection using OSNA and H&E techniques was made. Out of 1285 patients who underwent sentinel node (SLN) biopsy, 76 patients had micrometastases. Using H&E staining, 36 patients were detected with SLN micrometastases (9/year) in contrast to 40 patients in the OSNA year (40/year) (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f7cbae85717f41d182c826b0f28ac650 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF