Effects of dexamethasone on immune dysfunction and ventilator-associated pneumonia in COVID-19 acute respiratory distress syndrome: an observational study

Autor:	Martin Cour, Marie Simon, Laurent Argaud, Guillaume Monneret, Fabienne Venet
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	SARS-CoV-2 Monocyte HLA-DR CD4 + lymphocyte Nosocomial infection Intensive care unit Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Zdroj:	Journal of Intensive Care, Vol 9, Iss 1, Pp 1-4 (2021)
Druh dokumentu:	article
ISSN:	2052-0492
DOI:	10.1186/s40560-021-00580-6
Popis:	Abstract Dexamethasone improves survival of patients with COVID-19 acute respiratory distress syndrome, but might shorten the delay between the start of invasive mechanical ventilation and the occurrence of ventilator-associated pneumonia, suggesting possible worsening of COVID-19-induced immune dysfunction with this treatment. In a prospective observational study, we found that mechanically ventilated patients with COVID-19 treated with dexamethasone presented earlier ventilator-associated pneumonia, had significantly lower monocyte Human Leukocyte Antigen-DR expression and number of circulating CD4 + cells after ICU admission, than those not treated with corticoids.
Databáze:	Directory of Open Access Journals
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