| Autor: |
Baumann Marcus, Suttmann Yana, Heemann Uwe, Wassertheurer Siegfiried |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Artery Research, Vol 7, Iss 10 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1876-4401 |
| DOI: |
10.1016/j.artres.2013.10.032 |
| Popis: |
Objectives: Parameters associated with elevated arterial stiffness and structural vascular remodeling, like aortic pulse wave velocity, have been identified as important contributors to predict cardiovascular outcome in end stage renal disease but less is known about their value in early stages of chronic kidney disease (CKD). Methods: In order to investigate the progression of arterial stiffness markers in CKD we prospectively studied a cohort of 135 (41% female) patients with CKD stages 2/3/4 (N=20/75/40), and 89 (49% female) controls by cross sectional analysis in a first step. Subsequently we were able to follow up 129 patients for an average period of 42 months to evaluate the predictive value of arterial stiffness by means of central hemodynamics, pulse pressure amplification (PPA) and aortic pulse wave velocity (aPWV). Renal endpoints were halving of renal function and/or start of renal replacement therapy. Results: With respect to arterial function in cross sectional analysis augmentation index (AIx) and aortic pulse wave velocity (PWV) were significantly increased in CKD patients, whereas pulse pressure amplification (PPA) was reduced as compared to control subjects. In longitudinal analysis stratification according to CKD stage 2–4 PPA predicted renal endpoints whereas PWV was associated with mortality. Conclusion: PPA and PWV have been evidenced as predictor for cardiovascular morbidity and mortality. Within this cohort PPA was associated with the progression of CKD and PWV with mortality. |
| Databáze: |
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| Externí odkaz: |
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